氟康唑治疗复发性外阴阴道念珠菌病的疗效及安全性评价

Efficacy and Safety Evaluation about Fluconazole Sodium Chloride in the Treatment of Recurrent Vulvovaginal Candidiasis

目的探讨氟康唑用于治疗复发性外阴阴道念珠菌病的临床疗效及安全性。方法选取2012年8月—2013年8月我院就诊的复发性外阴阴道念珠菌病患者150例,随机分为观察组和对照组。对照组给予克霉唑阴道片治疗,观察组给予克霉唑阴道片联合氟康唑治疗。结果治疗1个月后,观察组总有效率(90.67%)高于对照组总有效率(78.67%),差异有统计学意义(P<0.05)。治疗2个月后,观察组总有效率(93.33%)高于对照组总有效率(81.33%),差异有统计学意义(P<0.05)。两组患者均未出现明显药物不良反应病例。结论氟康唑用于治疗复发性外阴阴道念珠菌病疗效可靠,具有良好的安全性。

Objective To explore the clinical efficacy and safety of fluconazole and sodium chloride in the treatment of recurrent vulvovaginal candidiasis. Methods A total of 150 vulvovaginal candidiasis patients who were admitted to our hospi- tal from August 2012 to August 2013, were selected as study subjects, then the patients were divided into the observation group and the control group. The control group were treated with clotrimazole vaginal tablets, and the observation group were treated with clotrimazole vaginal tablets combined with fluconazole and sodium chloride treatment. Results After 1 months of treat- ment, the total effective rate of the observation group （90. 67% ） was higher than that of the control group （78.67%）, and the difference was statistically significant （P 〈 0. 05） . After 2 months of treatment, the total effective rate of the observation group （93.33%） was higher than that of the control group （81.33%）, the difference was statistically significant （P 〈0. 05）. The two groups did not appear obvious adverse drug reaction cases. Conclusion The efficacy of fluconazole and sodium chloride in the treatment of recurrent vulvovaginal candidiasis is reliable and safety.