47例颅脑外伤术后颅内感染的相关危险因素分析

The Associated Risk Factors Analysis of 47 Cases with Postoperative Intracranial Infection after Craniocerebral Trauma

目的:探讨颅脑外伤术后颅内感染的相关危险因素分析,为临床提供参考。方法:采用病例对照研究方法,对我院自2010年6月至2013年6月间收治的47例发生颅脑外伤术后颅内感染患者作为感染组,选取同期47例未发生脑外伤术后颅内感染患者作为对照组,对有统计意义的单因素进行多因素非条件的Logistic回归分析。结果:单因素分析显示脑室外引流、手术时间、脑脊液漏、术后白蛋白、术前GCS评分、血糖水平、手术次数、术后激素、后颅窝手术是颅脑外伤术后颅内感染的危险因素,差异有统计学意义(P<0.05)。多因素非条件Logistic回归分析显示脑室外引流、手术时间、脑脊液漏、后颅窝手术及血糖等指标是颅脑外伤术后发生颅内感染的独立危险因素,差异具有统计学意义(P<0.05)。结论:脑室外引流、手术时间、脑脊液漏、后颅窝手术及血糖水平等因素是颅脑外伤术后颅内感染发生的独立危险因素。

Objective：To explore the Associated risk factors analysis of 47 cases with postoperative intracranial infection after Craniocerebral trauma, and it provides reference for clinical practice. Methods：By epidemiological case-control study method,47 patients with postoperative intracranial infection after Craniocerebral trauma were as infection group from June 2010 to June 2013, 47 cases with no postoperative intracranial infection in the same period were as the control group. Concerning statistically significant factors, many factors of unconditional Logistic regression analysis was adopted. Results ： Single factor analysis showed that Intraventricular external drainage, operation time, cerebrospinal fluid leakage, postoperative albumin, preoperative GCS score, blood sugar, posterior fossa surgery, surgery, postoperative hormone are risk factors of postoperative intracranial infection after Craniocerebral trauma, the difference was statistically significant （P 〈 0.05）. Many factors unconditional Logistic regression analysis revealed that Intraventricular external drainage, op- eration time, cerebrospinal fluid leakage, posterior fossa surgery and blood glucose level were independent risk factors of postoperative intracranial infection after Craniocerebral trauma, their difference was statistically significant （ P 〈 0.05 ）. Conclusion：Intraventricular external drainage, operation time, cerebrospinal fluid leakage, posterior fossa surgery and blood glucose level are independent risk factors of postoperative intracranial infection after Craniocerebral trauma.