中国人群TNF-α-308基因多态性与慢性HBV感染关联性的Meta分析

Association of TNF-α-308 polymorphisms with risk of chronic HBV infection in the Chinesepopulation： a Meta-analysis

目的探讨中国人群肿瘤坏死因子-α（TNF．Q）基因启动子区308位点多态性与慢性HBV感染的关联性。方法检索中外数据库于2001年1月至2013年5月公开发表的文献，纳入有关TNF-α-308基因多态性与慢性HBV感染关联的病例对照研究。对人选文献提取数据后，使用Stata12．0软件进行Meta分析。结果共纳入11项关于TNF-α-308基因多态性与慢性HBV感染关联的病例对照研究，其中病例组1872人，对照组1471人。Meta分析结果表明：在全部遗传模型中均能观察到A等位基因的保护作用（AVS．G：OR=O．579，95％CI：0．422～0．794；GAUS．GG：OR=O．525，95％CI：0．325～0．847；AAVS．GG：OR=O．301，95％CI：0．125～0．720；GA＋AA＋AAus．GG：OR=0．490，95％CI：0．309～0．777；AAVS．GA＋GG：OR=0．542，95％C1：0．394～0．746）。进一步分层分析显示，中国北方人群中TNF-α-308A等位基因的表达可以显著降低其慢性HBV感染的风险，而在选择自愈型患者作为对照和使用PCR作为检测手段的研究中并未发现A等位基因的保护作用。结论中国人群中TNF-α-308基因多态性与慢性HBV感染存在关联，携带A等位基因是慢性HBV感染的保护性因素。

Objective To explore the association between TNF-α gene 308 locus polymorphism and the risk of chronic HBV infection in Chinese population. Methods PubMed, Embase, CNKI and SinoMcd database were searched for relevant articles published from January 2001 to May 2013. Case-control studies on TNF-α-308 polymorphism with chronic HBV infection in Chinese population were gathered with meta-analysis applied for calculation of pooled OR value （with 95% C1） after data abstraction. Results Eleven case-control studies for the TNF-α-308 polymorphism with a total of 1 872 cases and 1 471 controls were included. Results from the overall meta-analysis indicated that-308A allele had a significant decreased risk of chronic HBV infection （A vs. G： 0R=0.579, 95%CI： 0.422-0.794; GA vs. GG： 0R=0.525,95%CI： 0.325-0.847; AA vs. GG： OR=0.301,95%CI： 0.125-0.720 ; GA ＋ AA vs. GG ： OR= 0.490, 95% CI： 0.309-0.777 ; AA vs. GA ＋ GG ： OR=0.542, 95%CI： 0.394-0.746）. In subgroup analyses by region, a significantly decreased risk seemed associated with -308A allele in population from northern China. When stratified by case type, control type and genotyping methods, there apppeared no significant association between TNF-α-308A allele and chronic HBV infection in the studies when spontaneously recovered one＇ s were used as controls and PCR used as its methodology. Conclusion TNF-α-308A allele seemed a protective factor for chronic HBV infection in the Chinese population.