幽门螺杆菌感染与慢性荨麻疹相关性的Meta分析

A Meta-analysis on the relations between Helicobacter pylori infection and chronic urticaria

目的探讨幽门螺杆菌（HP）感染与慢性荨麻疹发生的病因学关系。方法以HP、慢性荨麻疹为检索词，检索维普学术期刊数据库、中国期刊全文数据库、万方学术期刊数据库和PubMed数据库，筛选后纳入相关病例对照研究文献进行Meta分析，通过Stata软件计算合并OR值及其95％CI。结果入选研究共37项，累计慢性荨麻疹病例2909人，对照组1873人，数据表现为异质性。与对照组比较，HP感染增加慢性荨麻疹的发生风险（OR=3．20，95％CI：2．3l-4．43）。回归分析显示检测方法和地区分布是结论的重要影响因素。结论剧，感染与慢性荨麻疹发生存在相关性。研究结果与分布地区和检测方法有关。

Objective To investigate the relationship between Helicobacter pylori （HP） infection and the development of chronic urticaria. Methods Published case-control studies which concerned HI＇ infection related chronic urticaria were searched in Wanfang, CNKI, CQVIP Chinese databanks and PubMed. Meta-analysis was applied to analyze the pooled odds ratio （OR） and 95% confidence interval （CI）. Results 37 studies which comprised 2 909 cases of chronic urticaria and 1 873 persons served as controls were enrolled. When compared with the controls, HP infection significantly increased the risk of chronic urticaria development with a pooled OR of 3.20 （95%CI： 2.31-4.43）. Results from Meta-regression analyses showed that the distribution of residential areas and detection method being used were potential influential factors. Conclusion HP infection seemed to be associated with an increased risk of develol3in~ the chronic urticaria.