冲击伤后大鼠海马及脑干组织超微结构改变及其与肺冲击伤伤情的关系

UTRASTRUCTURAL ALTERATIONS OF HIPPOCAMPUS AND BRAIN STEM AND THEIR RELATIONSHIP WITH INJURY SEVERITY AFTER BLAST INJURY IN RATS

比较观察了胸部局部或全身冲击伤后大鼠海马和脑干组织超微结构改变及其与肺冲击伤伤情的关系。采用BST Ⅰ和BST Ⅲ型生物激波管分别致全身和胸部局部冲击伤。尸检显示 ,全身或胸部局部暴露冲击波仅导致明显的肺冲击伤 ,脑组织无明显的器质性损害。电镜结果显示 ,胸部局部或全身冲击伤后 ,海马和脑干神经细胞出现明显的结构改变 ,肺冲击伤伤情愈重 ,海马和脑干组织的超微结构改变也愈明显。提示全身或胸部局部冲击伤虽未引起脑组织肉眼上的明显损伤 ,但可造成海马和脑干组织超微结构的明显改变 ,并与肺冲击伤有一定的内在联系。

This experiment was to examine ultrastructural alterations in hippocampal and brain stem tissues and their relationship with injury severity after whole body or local chest exposure to blast wave in rats.BST Ⅰ and BST Ⅲ bio shock tubes were used to induce whole body or local chest blast injury.Gross examination revealed that only obvious pulmonary blast injury occurred after whole body or local chest exposure to blast wave,the brain tissue had no marked structural damage.Results from electron microscopy indicated that there were obvious ultrastructural alterations in the hippocampus and brain stem.The more severe the injury severity of pulmonary blast injury was,the more obvious alterations of brain ultrastructures occurred.It suggests that whole body or local pulmonary blast injury,although causing no marked gross alterations in the brain tissue,can inflict obvious ultrastructural damage in the hippocampus and brain stem,and this may be related with pulmonary blast injury.