子宫交界性平滑肌肿瘤增殖细胞核抗原表达的研究

Expression of PCNA in borderline uterine smooth muscle tumors

目的探讨子宫交界性平滑肌肿瘤（ＢＬＭ）细胞的增殖活性。方法应用抗 ＰＣＮＡ单克隆抗体，采用 Ｓ－Ｐ免疫组化方法对６３例子宫交界性平滑肌瘤和２０例普通于富平滑肌瘤（ＵＬ）及１０例子宫平滑肌肉瘤（ＬＭＳ）进行研究。结果 ９６．８％的子宫平滑肌肿瘤（ｕｓＭＴ） ＰＣＮＡ阳性，但 ＰＣＮＡ随恶性度增高强阳性率增加。结论在 ＳＳＭＴ中，ＰＣＮＡ的强阳性率随病理程度加重有增加趋势。提示 ＰＣＮＡ强阳性有助于 ＢＬＭ及 ＬＭＳ的诊断。

Objective To study the cellular proliferation activity of uterine smooth muscle tumors (USMT). Methods The expression of PCNA was studied by S-P immunostaining of monoclonal antibody (PC-10) in 93 case of USMT, of which borderline leiomyoma(BLM) was 63 cases, usual leiomyoma(UL) 20 cases, and leiomyosarcoma(LMS) 10 cases. Results The positive rate of PCNA was 96.8% (90/93) in USMT, hut strong positive rate of PCNA in each group was not significantly equal. Concusion The strong positive rate of PCNA showed an increasing tendency with a neoplastic change in USMT, whicih indicates strong positive rate of PCNA is useful in the diagnosis of BLM and LMS.