支气管哮喘诱导痰嗜酸性粒细胞阳离子蛋白与最大呼吸流速关系的研究

The relationship of bronchial asthma induced sputum eosinophils cationic protein and peak expiratory flow

目的 分析支哮喘急性发作期（中度）患者治疗前后最大呼吸流速与诱导痰ECP浓度变化关系,以及急性发作期诱导痰ECP浓度与PEF（%）的相关性,为指导支气管哮喘的治疗提供敏感指标,为进一步评估哮喘病情、支气管哮喘治疗的疗效提供价值更好的指标.方法 选取2012年3月～2013年3月在我院就诊的确诊为支气管哮喘急性期（中度）的患者60例,经沙美特罗替卡松治疗3个月前后进行肺功能PEF测定及诱导痰ECP浓度测定.结果 哮喘患者急性发作期治疗后较治疗前增加（P＜0.05）;哮喘患者急性发作期治疗后较治疗前ECP浓度水平降低;哮喘急性发作ECP浓度与PEF（%）者有相关性（r=-0.813,P＜0.01）,呈负相关.结论 根据ECP浓度变化能评估哮喘患者的治疗疗效以及联合使用ECP、PEF%对支气管哮喘患者的病情程度进行评估及对治疗疗效进行判定及跟踪.

Objective This study support forh acute exacerbation of asthma （moderate） treatment with the maximum flow rate of respiration induced sputum ECP change analysis, and research of acute exacerbation of induced sputum ECP and PEF （ % ） relevance for the treatment of bronchial asthma guidelines provide sensitive indicators, as well as to further assess asthma, bronchial asthma treatment efficacy to provide higher-value targets. Methods Select March 2012 N March 2013 in our hospital diagnosed as bronchial asthma acute phase （moderate） of 60 patients after salmeterol and fluticasone propionate before and after 3 months of treatment PEF measured pulmonary function and induced sputum ECP concentrations were measured. Results Acute exacerbation of asthma patients after treatment than before treatment increased （P 〈 0. 05 ） ;acute exacerbation of asthma patients after treatment than before treatment ECP levels decreased; asthma exacerbations ECP concentration and PEF （ % ） were correlated （ r = - 0. 813, P 〈 0.01 ）, a negative correlation. Conclusion According to the ECP concentrations to evaluate treatment efficacy in patients with asthma and joint use of ECP, PEF% of patients with bronchial asthma severity assessment and determine the efficacy of the treatment and tracking.