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突触前膜Ca^(2+)通道作为结构元件参与突触囊泡的停靠与融合 被引量：1

Presynaptic calcium channels contain structural elements participating in synaptic vesicle docking and fusion
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摘要 新近提供的证据表明 ,在神经递质释放中具关键作用的突触前膜Ca2 +通道 ,除为Ca2 +进入胞内提供路径外 ,还通过位于其胞内环 (LⅡ ～LⅢ)中的一段称为synprint位点的肽段与突触蛋白syntaxin和SNAP 2 5等相互作用 ,参与突触囊泡停靠 /融合。 Recent findings show that, besides mediating Ca 2+ entry as a pathway,presynaptic calcium channels,which play a crucial role in initiating neuroexocytosis, interact with the synaptic proteins,syntaxin and SNAP 25, through their synprint sites (synaptic protein interaction sites) located in the intracellular loops betweenⅡ～Ⅲ(L Ⅱ～L Ⅲ) of α subunits of N and P/Q type calcium channels directly participate in synaptic vesicle docking and fusion processes.
作者 丁军 施玉樑
机构地区 中国科学院上海生理研究所神经生物学开放研究实验室
出处 《中国神经科学杂志》 CSCD 2001年第1期55-58,共4页
基金 国家重点基础研究规划"脑功能和脑重大疾病的基础研究"!(G19990 5 40 0 0 ) 自然科学基金!(39870 2 49)
关键词 sYnprint 神经递质释放 突触囊泡 停靠 融合 钙离子通道 calcium channels synprint neurotransmitter release synaptic vesicle docking/fusion
分类号 R338.13 [医药卫生—人体生理学]
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参考文献22

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二级参考文献21

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中国神经科学杂志
2001年 第1期

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