亚临床甲状腺功能异常在妊娠早期妇女中检测的临床意义

Clinical significance of detection of subclinical thyroid dysfunction in early pregnancy pregnant women

目的分析妊娠早期妇女亚临床甲状腺功能异常的发病率。方法选择妊娠早期(<12周)女性1647例为实验组,体检科非妊娠育龄女性105例为对照组,测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、促甲状腺激素(TSH)的水平,以妊娠期及正常人群不同标准分析亚临床甲状腺功能异常的发病率。结果妊娠早期女性亚临床甲状腺疾病总患病率为19.06%,妊娠早期女性亚临床甲减的患病率为17.18%,与对照组比较P<0.05差异有统计学意义。结论采用妊娠期甲状腺功能检测范围筛查妊娠期妇女甲状腺功能,可正确评估妊娠妇女甲状腺功能,为优生优育提供一定基础。

Objective To anlysis the incidence about the subclinical thyroid dysfunction in first trimester pregnant women. Methods TSH,FT3 and FT4 were tested in 1647 first trimester pregnanct women and 105 nonpregnant women in reproductive age. Anlysis the incidence about the subclinical thyroid dysfunction according to the standards for the pregnant and nonpregnant women. Results The incidence of the subclinical thyroid dysfunction was 19.06% and the incidence of the subclinical hypothyroidism was 17.18% in the first trimester pregnanct women which were significantly higher than the control group （P 〈 0. 05）. Conclusion Evaluate the thyroid function of the pregnant women according to the standards for the pregnant women which provides the significance for prepotency.