摘要
以往报道表明 ,褪黑激素 (melatonin ,MEL)对癫活动有作用 ,但结果并不一致。有实验表明MEL有抗作用 ,也有证据支持MEL有促作用。本文用海马内微量注射的方法 ,观察了MEL对青霉素所致样发作 (penicillin inducedseizures ,PIS)的影响 ,并对其与受体的可能作用作了探讨。发现 ,预先给予MEL对PIS有抑制作用 ,且该效应具有剂量依赖性。褪黑激素的作用可被Ⅰ型受体拮抗剂luzindole部分阻断 ,而Ⅱ型受体拮抗剂prazosine对此无影响。结果表明 ,MEL对PIS有预防作用 。
Melatonin may play a role in epilepsy, but previous studies suggested anticonvulsant or proconvulsant effect. In this study, we investigated the effect of melatonin on benzylpenicillin induced seizures (PIS) as well as the interaction between melatonin and its specific receptors in rats. Seizure models were produced by microinjection of benzylpenicillin into rat hippocampus. EEG and behavior of the rat seizure models were monitored. Pretreated melatonin depressed PIS in a concentration dependent manner. The anticonvulsant effect of melatonin was partially blocked by the MEL 1 receptor antagonist, luzindole, whereas the MEL 2 receptor antagonist, prazosine, had no effect. The results indicate that melatonin has preventive effect against PIS, and it depresses PIS partially through specific MEL 1 receptor.
