慢性阻塞性肺疾病患者长期家庭氧疗后超声心动图测定指标的变化

Changes of ultra echocardiography in stable chronic obstructive pulmonary disease patients patients after long term domicilinary oxygen

目的 观察慢性阻塞性肺疾病 (COPD)低氧血症患者长期家庭氧疗 (LTOT)后超声心动图测定指标的变化。方法 22例 COPD低氧血症患者做超声心动图、测定右心室内径、右心室流出道大小以及左心房和左心室内径，计算右室流出道／左心房比值和左心室内径／右心室内径比值，并根据三尖瓣返流测定肺动脉平均压。然后分为 LTOT组和对照组。两组年龄、性别、肺功能和动脉血气无明显差别。两组均给予常规治疗， LTOT组开展家庭氧疗， 1年后复查超声心动图。结果 LTOT组患者 1年后的肺动脉平均压 (PAPm)下降。其他无明显变化。对照组患者 1年后与氧疗前相比右心室流出道增大和左心室内径 /右心室内径比值降低。结论 LTOT能减轻右心负荷，使右心结构和功能保持稳定。

Objective To observe the changes of ultra echocardiography in stable chronic obstructive pulmonary disease(COPD) with hypoxaemia after long term domicilinary oxygen therapy(LTOT).Methods Twenty two hypoxaemic patients with stable COPD were divided into two groups－ LTOT group of 12 patients and control group of 10 patients.ultra echocardiography were tested in both groups.Both groups received regular treatment and LTOT group received oxygen therapy ultraechocardiography were tested one year later. Results After one year,mean pulmonary artery pressure in the LTOT group declined.Others did not change significantly.But in the control group the load of right ventricle of the heart increased and the ratio of the inner diameter of left ventricle of the heart to right ventricle of the heart was significantly reduced.Conclusion Long term domiclinary oxygen therapy could reduce the load of the right heart and stabilize the construction and function of the ritght heart.