帕金森病患者载脂蛋白E基因多态性与痴呆相关性的分析

Analysis the polymorphism of apolipoprotein E gene in patients of parkinson disease with dementia

目的 了解帕金森病痴呆 (PDD)与载脂蛋白 E(apoE)基因多态性的关系，探讨 PDD的发病机制。方法 应用 PCR－ RFLP技术检测 11例 PDD患者， 40例帕金森病 (PD)非痴呆患者和 52例无关对照的 apoE基因型。结果 PDD组、 PD非痴呆组和对照组在 apoE等位基因频率及基因型分布上均无显著差异 (P >0.05)。结论 PDD的发病与 apoE基因多态性无关，其发病的生物遗传学基础有别于 Alzheimer病 (AD)。

Objective To study the relationship between PDD and the polymorphism of apolipoprotein E(apoE) gene,to inquire the etiological basis of PDD.Methods 11 Patients with PDD 40 patients with PD without dementtia and 52 unrelated controls were collected to detect the genotype of apoE gene by PCR－ RFLP. Results There was no difference in the apoE allele frequencies and genotype distribution in PDD group,PD without dementia group and control group(P >0.05). Conclusion There is no relationship between the polymorphism of apoEgene and the onset of PDD.The pathogenesis of PDD differs from that of AD.