持续气道正压治疗对睡眠呼吸暂停患者夜间多尿症状的影响及其与夜间心钠素水平的关系

Effect of treatment with continuous positive airway pressure on nocturnal polyuria in patients with obstructive sleep apnea syndrome： Relation with the plasma atrial natriuretic peptide in night

目的 研究持续气道正压（ CPAP）治疗对阻塞性睡眠呼吸暂停综合征（ OSAS）患者夜间多尿的影响及其与夜间心钠素水平的关系。方法 记录患者 CPAP治疗前后的夜尿次数、夜尿量、夜尿渗透压、夜尿钠排泄量和夜间心钠素 (ANP)。结果 CPAP治疗后 OSAS患者夜尿次数、夜尿量、夜尿钠排泄量明显减少，夜尿渗透压明显增高，夜间 ANP明显降低； ANP降低值与夜尿量、夜尿渗透压和夜尿钠排泄量的改变值有显著相关性。结论 CPAP治疗可明显减少 OSAS患者夜尿次数和夜尿量，减少夜尿钠排泄量，增加夜尿渗透压，这些改变可能与 ANP的降低有关。

Objective To investigate the effect of continuous positive airway pressure(CPAP) on nocturnal polyuria in patients with obstructive sleep apnea syndrome(OSAS). Methods The number of nocturia, the nocturia output, the osmotic pressure of nocturia and the nocturia excretion of Na＋ . Plasma levels of atrial natriuretic peptide (ANP) in night were measured in 8 patients. After treatment with CPAP, the patients were recorded or measured by those index again. Results The number of nocturia， The nocturia output， The osmotic pressure of Na＋ ,and the plasma leels of NAP in night decreased significantly after tretment with CPAP.The osmotic pressure of nocturia rose significantly.The reduction of ANP corrected with the reduciton of the nocturia output,addition of the osmotic pressure of nocturia and the reduction of the nocturia exeretion of Na＋ .Conclusion CPAP can reduce the number of nocturia, the nocturia output and the nocturia excretion of Na＋ , increase the osmotic pressure of nocturia. The changes probably relate with the reduction of plasma level of ANP.