慢性支气管炎、肺气肿患者弥散功能影响因素的分析

Effect of lung function factors on diffusing capacity in patients with chronic bronchitis and emphysema

目的 分析慢性支气管炎、阻塞性肺气肿患者其它肺功能因素对弥散功能的影响。方法 回顾性分析 120例慢支、肺气肿患者弥散功能正常组与异常组一氧化碳弥散 (DLco)与第一秒用力呼气量 (FEV1)、 RV/TLC、 PaO2的相关性。结果 慢支、肺气肿患者 DLco减低与 FEV1呈高度直线正相关，与 RV/TLC呈高度直线负相关， DLco异常组较 DLco正常组 PaO2减低。结论 慢支、肺气肿患者弥散功能减低与肺气肿毛细血管床丧失有关，亦与肺泡体积增大，通气功能减低所致通气 /血流异常有关。

Objective To investigate the effect of other lung function parameters on diffusing capacity in patients with chronic bronchitis and emphysema .Methods 120 patients with chronic bronchitis and emphysema were retrospectively studied.They were divided into two groups :normal DLco group and abnormal DLco group .The correlation of DLco with FEV1,RV/TLC and PaO2 was analyzed.Results In patients with chronic bronchitis and emphysema,DLco was reduced and positively correlated with FEV1,while it was negatively ,correlated with RV/TLC,PaO2 was lower in abnormal DLco group than in normal DLco group. Conclusions The reduced diffusing capacity in patients with chronic bronchitis and emphysema is related to the loss of lung capillary bed,abnormal ventilation/blood flow due to enlarged alveolar space and reduced ventiation.