多项诱发电位对职业中毒神经损害的初步研究

Multimodal evoked potentials in occupational intoxication

目的 研究多项诱发电位评估职业中毒神经损伤的临床价值。方法 对 27例职业中毒患者进行运动诱发电位 (MEP)、体感诱发电位 (SEP)、肋间体感诱发电位 (ISEP)、肌电图 (EMG)检测，同期作相关检查。结果 职业中毒男性患者 MEP上下肢皮层脊髓和女性左上肢、右下肢皮层和左下肢脊髓潜伏期（ PL）较正常人有显著改变（ P均 < 0.05），尿中重金属浓度与诱发电位 (EP)异常显著相关（γ =0.284;P< 0.05）。结论诱发电位技术是评估职业中毒伴中枢及周围神经中枢损害的一种较好方法。

Objective To study damage of occupational intoxication nervous system with multimodal evoked potentials. Method For 27 patients with GB clinically definited occupational intoxication.MEP result were compared with SEP、 ISEP、 EMG. Results There are significant difference in test of MEP in normal compared with occupational intoxication patients male and female right side upper limbs， left side lower extremity of cortex peak latent period（ P< 0.05） .Electrophysiology result had positive correlation with heavy metal concentration of urine, course of disease， serious disease and significance sign. (γ =0.284;P< 0.05)Conclusion It is a good method with multimodal evoked potentials might evaluate the central and peripheral nervous system lesion of occupational intoxication.