乙型肝炎病毒外膜大蛋白检测的应用价值及其研究进展

The application significance and research development of hepatitis B virus-large protein detection

目前乙型肝炎病毒(HBV)外膜大蛋白(LP)的研究尚处起步阶段,通过对HBV-LP的结构、功能、检测技术的发展历程及应用前景等进行阐述,说明HBV-LP与乙型肝炎血清标志物(HBV-M)、抗乙型肝炎病毒核心抗体IgM(HBcIgM)、HBV DNA等的协同检测,不仅可以提高乙型肝炎检出率,避免漏诊,而且可为临床评估HBV感染、复制、传染性及抗病毒治疗的疗效提供更为可靠的依据。

Currently, the research about hepatitis B virus（ HBV）-large surface protein （LP） is still in the infancy phase. The review describes the structure, function, testing technology and application prospects of HBV-LP and indicates the collaborative determination of hepatitis B serum marker （ HBV-M）, anti-hepatitis B virus core antibody IgM （HBcIgM） , HBV DNA with HBV-LP, which can not only improve the detection rate, avoid missed diagnosis, but also offer more reliable judgment reference for the clinical diagnosis of HBV infection, replication, infection judgment and antiviral efficacy index.