老年多梗塞性痴呆的性激素变化及相关因素的探讨

The study of sex hormones changes in multiple infarction dementia(MID) of old people and relevant elements

目的 研究老年多梗塞性痴呆 (MID)的性激素。方法 采取放射免疫法测定老年 MID46例，老年非痴呆脑梗塞 (CI)62例，老年健康对照组 38例。结果 男性和女性 MID组和 CI组分别与对照组比较，睾酮 (T)值下降， E2/T增高，均有显著性差异 ,男性 MID组雌二醇 (E2)高于对照组。女性 MID组和 CI组分别与对照组比较， T值下降，有显著性差异，女性 E2更明显下降，催乳素 (PRL)和孕酮 (RPO)及 E2/T值无显著性差异。男性上 NID与 CI组分别比较 T、 PRO、 E2/T均无显著性差异。结论 老年 MID与 CI都存在着性激素失衡，其中男性以 E2/T增高，女性以 E2降低最为明显。

Objective To study the changes of sex hormones in multiple infarction dementia (MID) of old people.Method To examine 46 old patients with MID and 62 old patients with non dementia cerebral infarction(CI) and 38 voluntxers with normal function.Result To compare male MID group,non dementia CI group with the control group respectively,the level of testosterones(T) was lower,E2/T was significantly higher.In MID group E2 was higher than control group,E2 was significantly higher.To compare non dementia CI group with the control group,E2/T was significantly higher.To compare non dementia CI group with the control group,E2 was not especially different.To compare female MID group,non dementia CI group with the control group respectively,the level of testosterones(T) was significantly lower,E2 was more significantly low.Prolactin(PRL),Progesterone(PRO) and E2/T were not especially different. Conclusion Sex hormone ballance was broken in MID and non dementia CI.E2/T was higher in male and E2 was obviously lower in female.