肝硬变腹水并发自发性腹膜炎的相关危险因素探讨

Analysis of the Risk Factors on Spontaneous Bacterial Peritonitis in Cirrhotic Patients with Ascities

目的:探讨肝硬变腹水患者并发自发性腹膜炎(SBP)的危险因素。方法:根据98例肝硬变患者的临床资料,分为SBP组和非SBP组,对其临床资料进行回顾性分析,并行Logistic回归分析。结果:2组患者在既往SBP病史、腹外感染、上消化道出血、腹水总蛋白、血清白蛋白、血清总胆红素、血钠水平、血清总胆固醇、凝血酶原时间、Child-pugh分级、糖尿病史等方面有显著性差异(P<0.05),而年龄、性别、肝硬变病因、血小板数、是否合并肝性脑病等因素无显著性差异(P>0.05)。经多因素Logistic回归分析发现:SBP病史、血清白蛋白、血清总胆红素是肝硬变腹水并发SBP的独立影响因素。结论:既往SBP病史、血清白蛋白、血清总胆红素3者可能是肝硬变腹水患者并发SBP的独立危险因素,需加以重视,并积极采取防治措施。

Objective： To analyse the risk factors of spontaneous bacterial peritonitis（SBP） in patients with liver cirrhotic and ascites. Methods：The clinical data of 98 patients, in which 38 cases were complicated by SBP（SBP group）and 60 cases were not（ non -SBP group）, were analyzed retrospectively. Results：There were significant differences in previous history of SBP, the infection in other parts except abdomen, diabetes, total protein in ascitic fluid, gastrointestinal bleeding, Child -Pugh classification, blood Na＋, serum TBil, ALB, PT and total cholesterol between the two groups （ P 〈 0.05 ） ; and no significant difierences were in sex, age, cause of cirrhosis, PLT and hepatic encephalopathy between the two groups （ P 〉 0. 05 ）. Logistic regression analysis showed that Previous history of SBP,TBil.ALB were significant independent factors to the development of SBP（ P 〈 0.05 ）. Conclusions ： Previous history of SBP,TBil ,ALB are independent risk factors of the development of SBP, we should pay more attention and take preventive measures.