重型颅脑损伤患者血清胃泌素水平测定及意义

Serum Gastrin Level in Patients with Severe Craniocerebral Injury and its Clinical Implication

目的 为探讨血清胃泌素与重型颅脑损伤后并发应激性溃疡之间的关系。方法 用放免法测定了重型颅脑损伤患者受伤后24h内的血清胃泌素水平,并对治疗期间出现应激性溃疡出血者出血后进行血清胃泌素的动态观察。结果 重型颅脑损伤后24h内的血清胃泌素水平较及正常对照组明显增高,且溃疡出血组出血后升高更显著。结论 胃泌素在重度颅脑损伤后应激性溃疡的发生发展中起重要作用。

Objective To evaluate the relationship between the variations of gastrin levels and the stress ulcer in the patients with severe head injury. Methods Seurm gastrin levels were serially determined by radiommunoassay in the 21 patients following severe head injury. Among them, 12 cases developed stress ulcers in the course of treatment. Nine healthy subjects were severed as control. Results On the first day after head injury,the mean level of serum gastrin was (176.91±38.53) pg/ml and significandy higher than that [(70.96±11.73) pg/ml] in the control group (p<0.01). In the stress ulcer group, the initial gastrin level increased markedly,but it dropped quickly in the 1st,the 3rd and the 7th day after the alimentary bleeding. Conclusion Gastrin might play an important part in the formation and progress of the stress ulcer in patients with severe head injury.