米索前列醇不同给药途径用于早期妊娠药物流产分析

Analysis on Different Routes of Administration of Misoprostol for Early Pregnancy

目的:分析米索前列醇不同给药途径用于早期妊娠药物流产的效果。方法:选择2010-2012年来本院要求终止妊娠的孕妇150例,分别采用口服米索前列醇、舌下含服米索前列醇、阴道放置米索前列醇三种途径进行终止妊娠。对三组的流产效果、不良反应、完全流产患者的孕囊排出时间以及阴道出血情况进行对比。结果:三组流产结果比较,阴道给药流产效果最好,舌下含服次之,口服最差;不良反应比较,口服组不良反应最多,舌下含服组次之,阴道给药组不良反应最少;孕囊排出时间比较,口服组时间最长,阴道给药组与舌下含服组较短,后两组比较差异无统计学意义。结论:在早期妊娠药物流产中米索前列醇不同给药途径的效果是不一样的,舌下含服和阴道给药的流产效果要优于口服用药。

Objective： To analyze effect of different routes of administration of misoprostol for early pregnancy.Method： 150 cases of pregnant women who request to terminate the pregnancy were chosen from 2010 to 2012.They were used oral misoprostol, contains sublingnal misoprostol, vaginal misoprostol placement to terminate a pregnancy, respectively. Effect of abortion, side effects, pregnant bursa discharge time and vaginal bleeding of patients with complete abortion in the three groups were compared. Result： In the resuhs of abortion, vaginal drug abortion effect was best, sublingnal administering times, oral was the worst. In the adverse reaction, oral group had most common adverse reactions, sublingual group, vaginal delivery group had minimal adverse reaction. In the gestation sac expulsion, oral group for the longest time, vaginal delivery group and sublingnal group was short, no significant differences between two groups.Conclusion： The effect of different routes of administration of misoprostol for early pregnancy is different, the effect of sublingual administering and vaginal drug abortion effect is better than that of oral medication.