摘要
AIM To explore the biotransformation of compound 7 (4 chlorbenzyl) 7,8,13,13a tetrahydroberberine in the rabbit. METHODS Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS A metabolite and unchanged 7 (4 chlorbenzyl) 7,8,13,13a tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION Compound 7 (4 chlorbenzyl) 7,8,13,13a tetrahydroberberine is metabolized by demethylation at 10 OCH 3 position.
AIM To explore the biotransformation of compound 7 (4 chlorbenzyl) 7,8,13,13a tetrahydroberberine in the rabbit. METHODS Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS A metabolite and unchanged 7 (4 chlorbenzyl) 7,8,13,13a tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION Compound 7 (4 chlorbenzyl) 7,8,13,13a tetrahydroberberine is metabolized by demethylation at 10 OCH 3 position.
出处
《药学学报》
CAS
CSCD
北大核心
2001年第2期137-139,共3页
Acta Pharmaceutica Sinica
