米非司酮联合桂枝茯苓胶囊对子宫内膜异位症患者血清血管内皮生长因子和基质金属蛋白酶-9的影响

The influence of mifepristone combined with Guizhifuling capsule on the serum VEGF and MMP-9 in the treatment of patients with endometriosis

目的 分析米非司酮联合桂枝茯苓胶囊对子宫内膜内膜异位症术后患者血清VEGF和基质金属蛋白酶-9（MMP-9）的影响.方法 76例子宫内膜异位症患者均采用手术治疗,术后按照数字表法随机分为对照组36例、观察组36例,对照组采用米非司酮治疗,观察组采用米非司酮联合桂枝茯苓胶囊治疗,比较两组临床疗效、血清VEGF和MMP-9的变化.结果 观察组有效率为94.4%,高于对照组的83.3%（χ^2=4.16,P＜0.05）.治疗后,观察组血清VEGF和MMP-9分别为（103.5±22.6） ng/L、（861.4±201.4） ng/L,对照组分别为（196.2±20.2） ng/L、（1 062.1±274.3） ng/L,两组治疗后血清VEGF和MMP-9均比治疗前明显降低（t =6.346 2、4.327 4、7.624 4、3.916 2,均P＜0.05）,与对照组比较,观察组下降更明显（t=2.724 6、2.924 4,均P＜0.05）.结论 米非司酮联合桂枝茯苓胶囊可以通过减少VEGF和MMP-9的表达而改善子宫内膜异位症患者病情.

Objective To analyze mifepristone combined with Guizhifuling capsule on serum vascular endothelial growth factor （VEGF） in patients with uterine endometriosis postoperative and matrix metalloproteinase-9 （MMP-9） effect.Methods 76 endometriosis patients were treated with operation,postoperative according to randomly divided into the control group（36 cases） and the observation group（36 cases）.The control group was treated with mifepristone,the observation group was treated with mifepristone combined with Guizhifuling capsule.The changes of serum VEGF and MMP-9 and the clinical curative effect were compared between the two groups.Results The effect rate of the observation group was 94.4%,which was higher than 83.3 % in the control group（x2 =4.16,P 〈 0.05）.The observation group after treatment,serum VEGF and MMP-9 were （103.5 ＆#177; 22.6） ng/L,（861.4 ＆#177; 201.4） ng/L,the control group were （196.2 ＆#177; 20.2） ng/L,（1 062.1 ＆#177; 274.3） ng/L,the two groups after treatment the serum VEGF and MMP-9 were significantly lower than those before treatment （t =6.346 2,4.327 4,7.624 4,3.916 2,all P 〈 0.05）,compared with the control group,the observation group decreased significantly （t =2.7246,2.9244,all P 〈 0.05）.Conclusion Mifepristone combined with Guizhifuling capsule can improve endometriosis patients by reducing the expression of VEGF and MMP-9.