经脐单孔腹腔镜与开腹胆囊切除术对患者肝功能和免疫功能的影响

Comparison of effects between transumbilical single port laparoscopic cholecystectomy and open cholecystectomy on hepatic function and immune function in patients with gallbladder diseases

目的 探讨经脐单孔腹腔镜与开腹胆囊切除术对患者肝功能和免疫功能的影响.方法 将120例胆囊炎、胆石症患者根据手术方式分为经脐单孔腹腔镜胆囊切除术组（NC组,58例）及开腹胆囊切除术组（OC组,62例）,均于术前1d及术后第3d检测肝功能和免疫功能,并进行比较分析.结果 NC组术后肝功能和免疫功能测定值与术前差异均无统计学意义（t =3.94、0.13、1.34、0.76,均P＞0.05）；而OC组术后肝功能和免疫功能测定值与术前差异均有统计学意义（t =27.04、34.49、18.52、21.45,均P＜0.05）；两组术后肝功能和免疫功能测定值差异均有统计学意义（t=15.31、31.42、12.32、12.68,均P＜0.05）.结论 经脐单孔腹腔镜胆囊切除术是安全可行的,其对肝功能和免疫功能的影响明显优于传统腹腔镜胆囊切除术.

Objective To study the effects between transumbilical single port laparoscopic cholecystectomy and open cholecystectomy on hepatic function and immune function in patients with gallbladder diseases.Methods 120 patients with gallbladder diseases were divided into NC group （n =58） and OC group（n =62）.Then to detect the change of serum hepatic function and immune function on one day before and 3 days after the operations.Results The levels of serum hepatic function and immune function in the NC group before and after the operations were no statistical significance （t =3.94,0.13,1.34,0.76,all P 〉 0.05）,while the levels of serum hepatic function and immune function in the OC group before and after the operations have significant statistical significance （t =27.04,34.49,18.52,21.45,all P 〈 0.05）.Conclusion Transumbilical single port laparoscopic cholecystect-omy is a safe and feasible operation,which has the advantages of less effects of hepatic function and immune function to compare with open cholecystectomy.