均匀设计法优选通心舒颗粒中药材的提取工艺

Optimization of the Extraction Technology of Medicinal Material from Tongxinshu Granules by Uniform Design

目的:优选通心舒颗粒中药材的提取工艺。方法:以加水倍数、浸泡时间、提取时间、提取次数为考察因素,以提取液中丹酚酸B转移率、芍药苷转移率及干膏得率为评价指标,采用均匀设计法优选工艺。结果:最优提取工艺为加9倍量的水,浸泡20min,提取3次,每次105 min。结论:优选的工艺简便、易行,稳定性好,可用于通心舒颗粒中药材的提取。

OBJECTIVE ： To optimize the extraction technology of medicinal material from Tongxinshu granules. METHODS ： The extraction technology was optimized by uniform design with the amount of water, soaking time, extraction time and extraction times as factors using transfer rate of salvianolic acid B and paeoniflorin and yield of dry extract as index. RESULTS： Optimized technology was as follows： 9-fold water, soaking for 20 min, extracting for 3 times, 105 min per time. CONCLUSIONS： The pre- ferred process is simple, easy, stable and suitable for the extraction of Tongxinshu granules.