淋巴管新生与肿瘤治疗
摘要
肿瘤细胞远处扩散(转移)是导致实体肿瘤愈后不良的主要原因。因此.从分子和细胞的水平上了解肿瘤细胞转移的机制,是肿瘤生物学研究的主要目的。在一个多世纪以前。StephenPaget提出的“种子和土壤”理论指出肿瘤细胞有向利于它生长的器官转移的倾向。
出处
《中国现代医药杂志》
2014年第2期106-109,共4页
Modern Medicine Journal of China
基金
湖南省高等学校科学研究项目(编号:09C841)
湖南省医药卫生科研计划课题(编号:2011-069)
参考文献41
-
1S Paget. The distribution of secondary growths in cancer of the breast[J].The Lancet,1889,(3421):571-573.
-
2J Ewing. Neoplastic Diseases[M].WB Saunders.Philadelphia Pa.USA,1928.1312.
-
3Norrme'n C,Tammela T,Petrova TV. Biological basis of therapeutic lymphangiogenesis[J].CIRCULATION,2011,(12):1335-1351.
-
4R Sathish Srinivasan,Xin Geng,Ying Yang. The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells[J].Genes & Development,2010,(07):696-707.
-
5Ran S,VoIk L,Hall K. Lymphangiogenesis and Lymphatic metastasis in breast cancer[J].PATHOPHYSIOLOGY,2010.229-251.
-
6Xu Y,Yuan L,Mak J. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3[J].Journal of Cell Biology,2010,(01):115-130.
-
7T Tammela,K Alitalo. Lymphangiogenesis:molecular mechanisms and future promise[J].CELL,2010,(04):460-476.
-
8E Bazigou,S Xie,C Chen. Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis[J].Developmental Cell,2009,(02):175-186.
-
9H Ungefroren,S Sebens,D Seidl. Interaction of tumor cells with the microenvironment[J].Cell Communication and Signaling,2011,(01):18.
-
10V Jsukov,K Pajusola,A Kaipainen. A novel vascular endothelial growth factor,VEGF-C,is a ligand for the Flt4(VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases[J].The EMBO Journal,1996,(07):1751.
二级参考文献44
-
1Zinovieva RD,Duncan MK,Johnson TR,et al. Structure and chromosomal localization of the human homeobox gene Prox 1[J].Genomics,1996,35(3):517-522.
-
2Alitalo K,Tammela T,Petrova TV. Lymphan giogenesis in development and human disease[J].Nature,2005,438(7070):946-953.
-
3Ho QT,Kuo CJ. Vascular endothelial growth factor:biology and therapeutic applications[J].Int J Biochem Cel Biol,2007,39(7-8):1349-1357.
-
4Karkkainen MJ,Makinen T,Alitalo K. Lymphatic endothelium:a new frontier of metastasis research[J].Nature Cell Biol,2002,4(1):E2-E5.
-
5Wigle JT,Harvey N,Detmar M,et al. An essential role for Prox-1 in the induction of the lymphatic endothelial cell phenotype[J].EMBO J,2002,21(7):1505-1513.
-
6Wilting J,Papoutsi M,Christ B,et al. The transcription factor Prox-1 is a marker for lymphatic endothelial cells in normal and diseased human tissues[J].FASEB J,2002,16(10):1271-1273.
-
7Pepper MS. Lymphangiogenesis and tumor metastasis:myth or reality?[J].Clin Cancer Res,2001,7(3):462-468.
-
8Van Trappen PO,Pepper MS. Lymphangiogenesis and lymph node microdissemination[J].Gynecol Oncol,2001,82(1):1-3.
-
9Sleeman JP. The lymph node as a bridgehead in the metastatic dissemination of tumors[J].Recent Results Cancer Res,2000,157:55-81.
-
10Sleeman JP,Krishnan J,Kirkin V,et al. Markers for the lymphatic endothelium:in search of the holy grail?[J].Microsc Res Tech,2001,55(2):61-69.
共引文献6
-
1杨红春,马海,王宇,陈运龙,李永.Prox1基因在原发性肝细胞癌中的表达及其与病理学分级及临床分期的相关性研究[J].中国普外基础与临床杂志,2011,18(7):737-740. 被引量:2
-
2李义强,赵春雨,李壮,王博.乳腺癌微淋巴管生成与淋巴道转移的关系[J].黑龙江医药科学,2012,35(2):65-66. 被引量:8
-
3王晓茹,白光辉.胃肠道间质瘤淋巴管及血管生成机制[J].山东医药,2016,56(13):40-42. 被引量:2
-
4杨光,张昆,王俊.Prospero相关同源异形盒蛋白1在非小细胞肺癌中的表达及意义[J].中国癌症杂志,2020,30(10):791-797. 被引量:1
-
5李冰,马起鹏,林林,刘畅.Prospero相关同源异形盒蛋白1在宫颈癌组织中的表达及其临床意义[J].东南大学学报(医学版),2021,40(3):376-380. 被引量:3
-
6刘菲,张晨曦,张苗苗,孙小莉,韩晨博,王佳.沉默PROX1基因对甲状腺乳头状癌TPC-1细胞的影响[J].局解手术学杂志,2021,30(12):1021-1024.
-
1Stephan Braun,Christian Marth,林宝琴.乳腺癌的循环癌细胞转向个体化治疗?[J].中国处方药,2004(11):81-83.
-
2张阳,鲁开化.炎性细胞与肿瘤的发生[J].医学综述,2004,10(2):80-81. 被引量:3
-
3董天庚,牛伟新.进展期胃癌淋巴结清扫范围的研究进展[J].国际外科学杂志,2009,36(5):341-344. 被引量:3
-
4虞文嫣,糜坚青.PET-CT在霍奇金淋巴瘤临床应用中的进展及思考[J].中华血液学杂志,2016,37(5):437-440. 被引量:1
-
5吴华英,向德兵.血管内皮生长因子在肿瘤血管生成的研究进展[J].中国肿瘤临床与康复,2012,19(5):470-471. 被引量:25
-
6郎荣刚,范宇,付丽.乳腺癌前哨淋巴结微小转移的检测及其意义[J].中华乳腺病杂志(电子版),2010,4(3):19-22. 被引量:2
-
7石海,许建明.胃癌预后影响因素的研究现状和进展[J].临床消化病杂志,2002,14(1):41-43. 被引量:12
-
8张保宁.乳腺癌保乳手术的研究进展[J].中国普外基础与临床杂志,2005,12(3):204-206. 被引量:103
-
9魏金旺,盛媛媛,钦伦秀.肿瘤的进化与异质性及其在转移中的意义[J].复旦学报(医学版),2016,43(1):122-126. 被引量:5
-
10姜军.乳腺癌临床治疗策略的研究进展[J].中国普外基础与临床杂志,2004,11(1):1-2. 被引量:15