per2基因参与边缘系统昼夜节律的研究进展

Advance in per2 Gene on Circadian Rhythm of Limbic System(review)

各种生物体生理、生化和行为过程都呈现一定的昼夜节律变化,并受到生物钟的调控。per2基因是重要的生物钟基因之一,主要分布在下丘脑的视交叉上核以及中央杏仁核、终纹床核、海马等边缘系统结构,通过参与该系统昼夜节律的调节对情绪和内脏活动产生影响。中枢per2基因的节律性通过对光信号、类固醇激素及其他相关递质的整合调节下丘脑-垂体-肾上腺(HPA)轴,作用于周围靶器官呈现昼夜节律性运动。本文对per2的形态学和生物学及其参与边缘系统对情绪、内脏活动昼夜节律调节机理做一概述。

Per2 gene plays one of the most critical roles of clock gene which modulates circadian rhythm both in the physiological, bio-chemical and behavioral processes of organisms. The distributions of per2 gene include suprachiasmatic nucleus of the hypothalamus, cen-tral nucleus of amygdala, bed nucleus of the stria terminalis, hippocampus and other components of limbic system;it affects the emotional and visceral activities through participating in the system of circadian rhythm. The central per2 gene regulates the hypothalamus-pituitary-adrenal axis through integration of light input, steroid hormones and other neurotransmitters integration, acting on the target organs, and pre-sentes a circadian rhythm of movement. This article reviewed the morphology and biology of per2 gene, and its participation in limbic sys-tem regulating the circadian rhythm of motional and visceral activities.