同期放化疗联合深部热疗治疗食管癌术后纵膈淋巴结转移的临床观察

Clinical Observation of Concurrent Chemo-Radiotherapy Combined with Deep Hyperthermia in Treatment of Esophageal Carcinoma with Mediastinal Lymph Node Metastasis after Surgery

目的探讨同期放化疗联合深部热疗治疗食管癌术后纵膈淋巴结转移患者的近期疗效及毒副反应。方法观察并分析川北医学院附属医院肿瘤科2011年6月-2013年1月收治的64例食管癌术后纵膈淋巴结转移患者，所有均接受同期放化疗联合深部热疗。结果深部热疗配合同期放化疗治疗食管癌术后纵膈淋巴结转移的总有效率为90．63％，其中完全缓解（CR）为42．19％，部分缓解（PR）为48．44％，且疗效与纵膈淋巴结的大小有关（P〈0．05）；其毒副反应以1～2级放射性食管炎、白细胞减少和放射性皮炎为主。结论同期放化疗联合深部热疗的治疗模式对于食管癌术后纵膈淋巴结转移的患者来说高效且较安全，其远期疗效值得进一步关注。

Objective To evaluate short-term effects and adverse reactions of the regimen of concurrent chemo-radiotherapy combined with deep hyperthermia in treating esophageal carcinoma with mediastinal lymph node metastasis after surgery. Methods Sixty-four patients of esophageal carcinoma with mediastinal lymph node metastasis after surgery from June 2011 to January 2013 in Affiliated Hospital of North Sichuan Medical College were enrolled. All patients received the treatment of deep hyperthermia combined with concurrent chemoradiotherapy. Results The total effective rate was 90. 63% , the complete remission rate was 42. 19%, and the partial remission rate was 48. 44%. The curative effect was related to the size of mediastinal lymph nodes. Acute radiation esophagitis, myelosuppression and dermatitis were the main side effects, primarily manifested as grade I or II. Conclusion The treatment regimen of deep hyperthermia combined with concurrent chemo-radiotherapy is very effective and safe, the long-term curative effect is worth our further attention.