幽门螺杆菌与胃粘膜癌前病变关系的探讨

RELATIONSHIP BETWEEN HELICOBACTER PYLORI(HP) AND PRECANCEROUS LESION OF GASTRIC MUCOSA

为探讨幽门螺杆菌 (HP)与胃粘膜癌前病变的关系 ,总结分析了 2 987例因患胃及十二指肠疾病就医的患者。检查出 HP阳性 1 5 80例 ,占总例数的 5 2 .9%。HP阳性患者痿缩、肠化和异增的发生率分别为 2 2 .7% ,8.6 %和 4.4% ,均显著高于 HP阴性患者的发生率 1 2 .4% ,6 .5 %和 2 .8% (P<0 .0 1或 0 .0 5 ) ,提示上述 3种胃癌前病变可能与 HP感染有关。HP阳性患者发生痿缩、肠化和异增的平均年龄分别为 46 .8,47.0和 44.3,与 HP阴性患者发生这 3种病变的平均年龄无显著性差异。对 HP阳性和阴性患者痿缩、肠化和异增程度也作了对比分析 ,二者之间也未见显著不同。并就HP在胃癌多阶段、多病因学说中的地位和作用进行了分析探讨。

To investigate the relationship between helicobacter Pylori(HP) and Precancerous Lesion of Gastric Mucosa, 2 987 cases of gastroduodenal disease were analysed. The results examined showed that HP\|positive lesions were 1 580 cases(52.8% of total cases). The incidences of atrophy,intestinal metoplasia and dysplasia were 22.7%,8.6%and 4.4% for HP\|positive, and 12.4%,6.5% and 2.8% for HP\|negative, respectively. The former was significantly higher than the latter, respectively( P <0.01 or 0.05). This suggests that the above\|mentioned 3 kinds of gastric precanerous lesions might relate to HP infection. The average age of HP\|positive lesion for atrophy, intestinal metoplasia and dysplasia were 46.8,47.0 and 44.3 respectively, having no distinct difference as compared with HP\|negative. In addition, a comparative analysis of, the degree of 3 kinds of precancerous lesion in both cases was made and no marked disparity was found.