食物特异性IgG的检测与儿童过敏性紫癜的相关性研究

Correlative study on food IgG specificity and henoch-schonlein purpura in children

目的探讨食物特异性IgG与儿童过敏性紫癜的相关性及其与紫癜性肾炎患儿肾损伤的相关性。方法分别采用ELISA法和自动生化仪免疫比浊法检测140例过敏性紫癜患儿血清14种食物特异性IgG浓度及血清总IgG。结果过敏性紫癜患儿食物不耐受阳性率为91.43%,鸡蛋的阳性率最高,其次为牛奶、鳕鱼、螃蟹、虾等。食物不耐受种类在不同年龄组间有差异,食物不耐受阳性率在不同年龄组间差异无统计学意义。食物不耐受累计敏感度与血清IgG浓度无直线相关。食物不耐受在过敏性紫癜患儿及紫癜性肾炎患儿中差异无统计学意义,紫癜性肾炎患儿食物不耐受与其肾脏病理中免疫复合物沉积无相关性。结论儿童过敏性紫癜的发生与食物不耐受关系密切,但食物不耐受与患儿肾脏损伤无相关关系。

Objective To explore the correlation between food IgG specificity and henoeh-schonlein purpura （HSP） in children and the correlation between renal injury in henoeh-sehonlein purpura nephritist （HSPN）. Method The levels of IgG against 14 common food were measured by ELISA and the serum total IgG by automatic biochemical analyzer immuno- turbidimetry were obtained from 140 children with HSP. Results Total positive rate of serum food-intolerant IgG anti- bodies in HSP children was 91. 43%. Among these 14 intolerant foods, the positive percentage of egg was the highest （30.4%） ,followed by milk（26.52%） ,morrhua （12.17%/00） ,crab （7.54%） and shrimp（6.08%）. The sort of intolerant food differed between different age groups. But significant differences of the food intolerance positive rate did not exist among dif-ferent age groups. There was no linear correlation between total food intolerance and serum IgG level. The difference of food intolerance between HSP and HSPN were not statistically significant. Food intolerance had no relation to immune complex deposition in kidneys of HSP nephritis. Conclusions HSP is closely related to food intolerance,but it seems that food in- tolerance has no relation to renal damage.