菝葜的化学成分研究（英文）

Chemical Constituents from Rhizomes of Smilax china Linn.

采用常压柱色谱和制备型高效液相色谱等色谱方法,从菝葜根茎中分离得到12个化合物,通过理化性质和波谱分析鉴定为(2R,3R)-二氢山奈酚-3-O-β-D-葡萄糖苷(1),(2R,3R)-二氢槲皮素-3-O-β-D-葡萄糖苷(2),落新妇苷(3),异落新妇苷(4),3,5,7,3',5'-五羟基-2R,3R-二氢黄酮-3-O-α-L-鼠李糖苷(5),芦丁(6),紫云英苷(7),4,6-二羟基苯乙酮-2-O-β-D-葡萄糖苷(8),4,6-二羟基苯甲酸甲酯-2-O-β-D-葡萄糖苷(9),氧化白藜芦醇(10),原薯蓣皂苷(11),薯蓣皂苷(12).化合物1,4-5,7-9为首次从该植物中分离得到.此外,通过比较菝葜和土茯苓中化学成分的差异,发现菝葜的主要成分为甾体皂苷和黄酮类化合物,而土茯苓中主要为黄酮类化合物.

12 compounds are isolated from the rhizomes of Smilax china Linn. by various column chromatographic methods, including open column and preparative HPLC. Their structures are elucidated as （2R, 3R） - dihydrokaempferol - 3 - 0 -β - D - glucopyranoside （ 1 ）, （2R, 3R） - dihydroquercetin - 3 - 0 -β - D - glueopyranoside （2）, astilbin （3）, isoastilbin （4）, 3, 5, 7, 3＇, 5＇- pentahydroxy- （2R, 3R） -flavanonol-3- 0 -a -L -rhamnopyranoside （5）, turin （6）, astragalin （7）, 4, 6 - dihydroxy -2 - 0 - （/3 - D - glucopyr- anosyl） acetophenone （8）, methyl 2 - 0 -/3 - D - glucopyranosyl - 2, 4, 6 - trihydroxybenzoate （9）, oxyres- veratrol （10）, protodioscin （11）, dioscin （12） by spectral analysis as well as physical and chemical properties. Compounds 1, 4 - 5, 7 - 9 are obtained from S. china for the first time. In addition, based on the contrast of chemical constituents between Smilax china Linn. and Smilax glabra Roxb. , it is concluded that steroid saponins and flavonoids are the major chemical constituents of S. china, while S. glabra holds flavonoids as the major chemical constituents.