胸腺激素类药致少见不良反应分析

Analysis of Thymic Hormones-caused Rare ADR

目的:探讨胸腺激素类药致少见药品不良反应(ADR)的特点及规律,为临床合理用药提供依据。方法:以胸腺肽、胸腺肽α1、胸腺五肽、胸腺肽注射液、注射用胸腺肽等为主题词、关键词,对2004年1月-2013年8月报道胸腺激素类药致少见ADR的文献进行分析。结果:纳入研究文献59篇,病例77例。胸腺激素类药致过敏性休克56例,其中死亡2例;精神抑郁4例;关节痛4例;月经失调3例;室上性心动过速3例;急性脱髓鞘性脑病2例;腓神经炎1例;脓疱疹1例;咯血1例;哮喘1例等少见ADR。结论:胸腺激素类药致少见ADR的原因可能与用药人的体质、给药途径、用药剂量、用药品种及超说明书用药有关。

OBJECTIVE： To investigate the characteristics and regularity of thymic hormone-caused rare ADR, and to provide reference for rational drug use in the clinic. METHODS： Thymosin, thymosin a1, thymopentin, thymosin injection, injection of thymosin as the theme/keyword report during Jan. 2004-- Aug. 2013 thymic hormone drugs cause rare ADR literature analysis. RE- SULTS： 59 research literatures were included, involving 77 cases. There were 56 cases of thymic hormone-induced anaphylactic shock, including 2 cases of death, 4 cases of mental depression, 4 cases of joint pain, 3 cases of menstrual disorders, 3 cases of supraventricular tachycardia, 2 cases of acute demyelinating encephalopathy, a case of philippians neuritis, a case of impetigo, a case of hemoptysis, a case of asthma, etc. CONCLUSIONS： Thymic hormone-caused rare ADR may be related to patient＇ s consti- tution, route of administration, dosage, drug varieties and off-label drug use.