功能性磁共振在冠脉搭桥术后认知功能障碍的研究现状

A review of functional magnetic resonance imaging for postoperative cognitive dysfunction associated with coronary artery bypass surgery

背景术后认知功能障碍（postoperativecognitivedysfunetion，POCD）的危害正日益受到人们的重视，特别是对老年人的影响。目前，功能性核磁共振（funetionalmagneticresonanceimaging，fMRI）作为一种有效而无创的检查方法，被广泛应用于认知神经科学研究领域。目的探讨POCD诊疗的研究现状。内容对冠脉搭桥术后POCD的诊断、发病机制及fMRI在诊断POCD中的应用作一综述。趋向引起POCD的影响因素诸多，但病因和发病机制尚未明确，寻找一个行之有效的防治手段，尤为重要。

Background More and more attention has been paid to the endanger of postoperative cognitive dysfunction （POCD）, especially in the elderly. Currently, functional magnetic resonance imaging （fMRI） is a powerful, noninvasive research method which can be widely used in the field of cognitive neuroscienee. Objective The purpose of this review is to discuss recent development in the pathogenesis and diagnosis of POCD. Content This review will discuss the diagnosis, pathogenesis of POCD associated with coronary artery bypass surgery and the efficacy of fMRI in diagnosis of POCD. Trend There are many factors leading to POCD, but the etiology and pathogenesis is not clear yet. An effective mean of prevention is particularly important.