EphA4在人上皮性卵巢癌中的表达及临床意义

Expression of EphA4 in Epithelial Ovarian Cancer and Its Clinical Significance

目的:研究EphA4在卵巢肿瘤组织中的表达,并分析其生物学特性及临床意义。方法:应用免疫组织化学方法检测84例卵巢癌和20例卵巢良性肿瘤组织中EphA4蛋白的表达;应用原位分子杂交法检测上述组织中EphA4mRNA的表达。结果:EphA4蛋白及EphA4mRNA在卵巢癌中的表达明显高于卵巢良性肿瘤(P<0.01);EphA4蛋白和EphA4mRNA的表达在卵巢癌组织学分级,临床分期和淋巴结转移的分组比较中差异具有统计学意义(P<0.05),而与患者的年龄、组织学分型及有无腹水等无关(P>0.05)。结论:EphA4的过表达可能促进卵巢癌的进展和转移,可以作为判断卵巢癌预后的重要指标。

Objective： To investigate the expression and clinical value of EphA4 in epithelial ovarian cancer, and to analyze its biological characteristics. Methods ： The expression of EphA4 in 84 cases of epithelial ovarian cancers and 20 cases of benign ovarian tumors were detected by immunohistochemistry. The expressions of EphA4mRNA in these tissues were examined by in situ hybridization（ISH）. Results： The level of EphA4 and EphA4mRNA expression in epithelial o- varian cancer was significantly higher than that in benign ovarian tumor, respetively （P 〈 0.01 ）. The expression of EphA4 and EphA4mRNA were related to histological grade , clinical stages and lymph node metastasis （P 〈 0.05）, but not age, pathologic types and the amount of ascites （P 〉 0.05 ）. Conclusion ： EphA4 overexpression may promote the progression and metastasis of epithelial ovarian cancer. It may be an important predictive target.