淫羊藿苷的稳定性及其影响因素

Stability of Icariside and Factors Affecting the Stability

目的：分析测定淫羊藿苷在不同条件下的稳定性及其影响因素.方法：采用紫外-可见分光光度法在200 ～600nm扫描,测定不同条件下对淫羊藿苷结构的影响.结果：在微酸性、微碱性和中性条件下,淫羊藿苷可保持结构稳定.在pH ＜2和pH＞ 10时,结构发生明显变化;淫羊藿苷热稳定性较好,在100℃长时间加热其仍可以稳定存在;能与过渡金属离子Cu2＋,Fe3＋,Al3＋形成络合物,对淫羊藿苷的氧化起到了诱导催化作用从而对其结构有明显的影响.结论：紫外-可见光谱法能够初步考察不同条件下对淫羊藿苷稳定性的影响,为淫羊藿苷的提取、制剂和衍生物制备等提供重要信息.

Objective：To analyze and determine the stability of icariside and its factors affecting in different conditions.Method：On the basis of ultraviolet-visible spectrum under 200-600 nm region scan,determine the factors affecting the chemical structure of icariside in different conditions.Result：Icariside was stable in water,incruding slightly acidic,basic and neutral conditions.When it existed in aqueous phase under pH ＜ 2 or pH ＞ 10 conditions,the chemical structure of icariside was changed.Furthermore,its aqueous phase under 100 ℃ for a long time was remain stable.In the processes of extracting and using icariside,metal ion such as Cu2＋,Fe3＋ and Al3＋ should be wiped off,as they were able to chelate with icariside,and could induce oxidation as well.Conclusion：Using ultraviolet-visible spectrum can primary observation the factors affecting the stability of icariside in different conditions,and providing important information on its extraction,preparation and derivatives preparation.