沙参麦冬汤加减对恶性肿瘤增效减毒作用的系统评价

A System Evalution of Randomized Controolled Trials of Modified Shashen Maidong Decoction for Cancer

目的:评价沙参麦冬汤加减对恶性肿瘤的增效减毒作用。方法:按照循证医学的要求,电子检索2000年12月25日至2012年12月25日期间Pubmed、中国学位论文全文数据库、中国生物医学文献数据库、维普数据库、中国学术期刊网络出版总库、中国知网等数据库,有关沙参麦冬汤加减对恶性肿瘤增效减毒作用的随机对照研究文献。运用改良后Jadad量表评价纳入文献的方法学质量并提取有效数据进行Meta分析,用RevMan5.0软件完成统计和系统评价。结果:共14篇文献包含1 193例患者符合纳入标准,其中1篇文献病例来源马来西亚,余下皆来自中国。1篇评为高质量,其余为低质量。Meta分析表明,沙参麦冬汤联合组治疗恶性肿瘤的客观疗效优于对照组,[OR为2.01,95%CI(1.39,2.92)],其差异有统计学意义,沙参麦冬汤联合组治疗恶性肿瘤出现的不良反应也较对照组少。结论:沙参麦冬汤联合组对恶性肿瘤的增效减毒作用优于对照组。

Objective：To assess the therapeutic effect and safety of modified Shashen Maidong decoction in the treatment of carcinoma.Method：Literatures regarding randomized clinical trials of modified Shashen Maidong decoction in treating cancerous fever were revewed.According to inclusion standard and the elimination standard,related literatures were selected and analysed according to different treatment strategies of trials.The methodological quality of the included trials was assessed and Meta-analysis was performed with Revman 5.0 software.Result：Fourteen randomized clinical trials （n =1 193） were identified the methodological quality only one ranked high.Meta-analysis indicated that modified Shashen Maidong decoction was more effective than western medicine [OR 2.01,95％ CI （1.39,2.92）] in the treatment of carcinoma.Seven articles reported side effects and no serious adverse events were reported.Conclusion：modified Shashen Maidong decoction may be effective in the treatment of carcinoma,however,the evidence is not strong due to the variations of the herbs,more randomized clinical trials are required.