新型非典型抗精神病药鲁拉西酮及其临床应用进展

Advance of novel atypical antipsychotic drug lurasidone and the clinical application

鲁拉西酮是一种新型非典型抗精神病药,对多巴胺D2受体、5-HT2A受体及5-HT7受体具有高度亲和力,已经被FDA批准用于治疗成人精神分裂症和双相障碍重性抑郁发作。本文对该药的药理作用、药代动力学、药物相互作用、临床应用、安全性及耐受性进行综述。

Lurasidone is a novel atypical antipsychotic drug with high affinity for D2, 5 - HT2A and 5 - HT7 receptors. Lurasidone has received accelerated approval from the FDA for the treatment of adult schizophrenia and bipolar depression. The article is to provide an up - to - date review about the mechanism of action, pharmacokinetics, drug - drug interaction, clinical application, safety and tolerance of lurasidone.