摘要
随着对抗结核免疫机制的深入研究,新型结核疫苗的研发也更加理性和成熟。近期研究表明,CD4 T细胞多功能至关重要,人类CD8和γδT细胞也有抗结核免疫保护作用,是新型疫苗设计有潜力的T细胞靶点。系统的"组学"技术大规模筛选有可能发现更多强免疫原性的抗原。不同表达时期的多抗原组成的多价疫苗对不同感染时期的结核都有预防作用。针对潜伏感染或已经感染个体配合化学药物使用的新型治疗性疫苗,有望促进清除残留的结核分枝杆菌。
The design of new tuberculosis （TB） vaccines becomes more rational thanks to the in-depth studies of anti-tuberculosis immunity and mechanisms. Recent studies have demonstrated that while CD4^＋ T cells are crucial for anti-TB immunity, primate CD8 and γδ T cells are also protective and can serve as potential targets for TB vaccine design. High-throughput screening will help to identify more potent or protective antigens. Combined utilization of antigens expressed in different stages of Mycobacterium tuberculosis （Mtb） growth might effectively protect against Mtb infection. It is also hopeful that therapeutic vaccines in combination with anti-TB drugs can more effectively eliminate latent Mtb infection.
出处
《生命的化学》
CAS
CSCD
2014年第1期39-45,共7页
Chemistry of Life
基金
十二五传染病重大专项(2013ZX10003009-002)
上海巴斯德基金会项目(SPHRF2013001)
关键词
疫苗靶点
新型抗原
治疗性疫苗
vaccine T cell targets
novel antigens
therapeutic vaccine
