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司美替尼联合多西紫杉醇治疗KRAS突变阳性晚期非小细胞肺癌的疗效

Efficacy of Selumetinib plus Docetaxel for KRAS-Mutant Advanced Non-Small Cell Lung Cancer
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摘要 1文献来源 Janne PA, Shaw AT, Pereira JR, et al. Selumetinib plus Docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study [J].
出处 《循证医学》 CSCD 2014年第1期30-32,共3页 The Journal of Evidence-Based Medicine
关键词 晚期非小细胞肺癌 司美替尼 临床试验 Ⅱ期 advanced non-small cell lung cancer Selumetinib clinical trial, phase II
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参考文献6

  • 1Hainsworth JD,Cebotaru CL,Kanarev V. A phase Ⅱ,open-label,randomized study to assess the efficacy and safety of AZD6244 (ARRY-142886) versus Pemetrexed in patients With non-small cell lung cancer who have failed one or two prior chemotherapeutic regimens[J].JOURNAL OF THORACIC ONCOLOGY,2010,(10):1630-1636.
  • 2Levy B,Drilon A1,Chachoua A. KRAS mutations predict sensitivity to Pemetrexed-based chemotherapy[J].Lung Cancer Management,2013,(04):275-280.
  • 3Holt SV,Logié A,Odedra R. The MEK1/2 inhibitor,Selumetinib (AZD6244;ARRY-142886),enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models[J].British Journal of Cancer,2012,(05):858-866.
  • 4Janne PA,Shaw AT,Pereira JR. Selumetinib plus Docetaxel for KRAS-mutant advanced non-small-cell lung cancer:A randomised,multicentre,placebo-controlled,phase 2 study[J].The Lancet Oncology,2013,(01):38-47.
  • 5de Roock W,Jonker DJ,Di Nicolantonio F. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with Cetuximab[J].Journal of the American Medical Association,2010,(16):1812-1820.
  • 6Chen Z,Cheng K,Walton Z. A murine lung cancer coclinical trial identifies genetic modifiers of therapeutic response[J].NATURE,2012,(7391):613-617.

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