摘要
利用Sephadex LH-20凝胶柱层析、硅胶柱层析、HPLC等多种柱色谱手段对中国南海隋氏蒂壳海绵Theonellaswinhoei化学成分进行分离提纯;通过波谱解析结合文献对照,鉴定化合物的结构。从其正丁醇萃取部位首次分离鉴定了6个化合物:thymidine(1),thymidine-5'-carboxylic acidmethylester(2),thymidine-5'-carboxylic acid butyl ester(3),uracil(4),thymine(5),7,8-Dimethyl-iso-alloxazine(6)。
Sephadex LH-20 columnchromatography, silica column chromatography and HPLC methods were used to iso- late and refine compounds from sponge Theonellaswinhoei from the South China Sea. The structures were identified by spectroscopic analysis and comparison with the literatures. From the n-BuOH soluble extract of Theonellaswinhoei, six compounds were isolated for the first time and their structures were determined as thymidine ( 1 ), thymidine-5'-carboxylie acid methyl ester(2) ,thymidine-5'-earboxylie acid butyl ester(3),uracil(4),thymine(5),7,8-Dimethyl-iso-alloxazine (6).
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第2期209-211,共3页
Natural Product Research and Development
基金
上海市科委工程中心建设:上海水产品加工及贮藏工程技术研究中心(11DZ2280300)
关键词
海绵
化学成分
结构鉴定
sponge
chemical constituents
structural identification