二甲双胍联合能量摄入限制治疗非酒精性脂肪肝疗效观察

Metformin Combined with Energy Intake Restriction to the Treatment of Non-alcoholic Fatty Liver

目的:观察二甲双胍联合能量摄入限制治疗非酒精性脂肪肝的疗效。方法:将78例非酒精性脂肪肝患者分为两组,分别给予二甲双胍和多烯磷脂酰胆碱胶囊(易善复)治疗,观察两组每月治疗效果及疗程结束后所有生化指标及肝脏B超。结果:两组患者在临床症状改善、肝功能好转上、总有效率无显著差异(P>0.05),血脂下降和肝B超改善率有差异性(P<0.05),不良反应发生率均较低。结论:二甲双胍联合能量摄入控制治疗非酒精性脂肪肝患者疗效、安全性好,且在降血脂方面有一定效果。

Objective： To observe the metformin combined with energy intake restriction and treatment of non-alcoholic fatty liver. Methods： 78 patients with non-alcoholic fatty liver patients were divided into two groups, were given metformin and polyene phosphatidyl choline capsules （Essentiale） treatment, observed two sets of monthly treatment effect after the end of treatment biochemical markers and liver B. Results： The patients in the improvement of clinical symptoms, liver function improved, the total effective rate was no significant difference （P〉0. 05）, lipids decreased and liver B-improvement rate differences （P〈0. 05）, adverse reaction rates than is low. Conclusion： Metformin joint energy intake control efficacy in patients with treatment of nonalcoholic fatty liver, security, and have some effect in lowering blood pressure.