中国人群HLA-DQB1基因多态性与乙肝肝硬化关联性的Meta分析

Relationship between HLA-DQB1 Gene Polymorphism and Hepatitis B-Related Liver Cirrhosis in Chinese People: A Meta-Analysis

目的综合评价中国人群HLA-DQB1基因多态性与乙肝肝硬化的关联性。方法计算机检索MEDLINE、中国生物医学文献数据库(CBM)、中国知识资源总库(CNKI)、万方数据库收录的中英文文献,收集有关中国人群HLA-DQB1基因多态性与乙肝肝硬化关联性的文献随机对照试验,检索年限为1996年6月至2012年2月。根据NOS评分系统对纳入文献进行质量评估。采用Stata11.0软件进行Meta分析。结果纳入文献共5篇。Meta分析结果表明,HLA-DQB1*02可能为乙肝肝硬化的易感性基因(P<0.05)。Meta分析不存在发表偏倚。结论 HLA-DQB1*02基因可能为中国人群乙肝肝硬化的易感性基因。

Objective To assess the relationship between HLA-DQB1 gene polymorphism and hepatitis B-related liver cirrhosis in Chinese people.Methods MEDLINE,CBM,CNKI,Wanfang Database were searched for the randomized controlled trials（RCTs）,which studied on the relationship between HLA-DQB1 gene polymorphism and hepatitis B-related liver cirrhosis in Chinese people,from June 1996 to February 2012.Newcastle-Ottawa Scale（NOS） was used to evaluate the included studies.Stata 11.0 software was used to conduct a meta-analysis.Results A total of 5 trials were analyzed.The meta-analysis suggested that HLA-DQB1＊02 might be significantly associated with the risk of hepatitis B-related liver cirrhosis（P〈0.05）.There was no publication bias in the meta-analysis.Conclusion HLA-DQB1＊02 might be the susceptible gene of hepatitis B-related liver cirrhosis in Chinese people .