冠心宁注射液对脑出血后脑心综合征治疗作用的研究

The therapeutic effect of guanxinning injection on cerebrocardiac syndrome induced by cerebral hemorrhage

目的:观察冠心宁注射液治疗脑出血后脑心综合征患者的有效性。方法:将62例脑出血后脑心综合征患者按是否使用冠心宁注射液而分为治疗组和对照组,治疗组(32例)采用常规冶疗基础上加用冠心宁注射液冶疗,对照组(30例)给予常规治疗,分析2组患者临床症状、心电图、血清心肌酶谱水平的变化及不良反应。结果:冶疗组总有效率(84.38%)明显高于对照组(53.33%)(P<0.01);治疗组治疗后血清AST、LDH、CK、MB含量分别为(65.59±13.71)、(100.22±17.69)、(40.18±9.46)、(280.82±20.84)IU/L,对照组冶疗后血清AST、LDH、CK、MB含量分别为(132.22±16.78)、(219.97±29.54)、(84.13±11.62)、(422.51±33.7 6)IU/L,治疗组冶疗后血清心肌酶谱水平皆明显低于对照组(P<0.001);两组皆无明显负反应。结论:冠心宁注射液能改善脑出血后脑心综合征患者的临床症状,纠正其心电异常,下调其心肌酶谱水平。

Objective：To observe the effectiveness of Guanxinning injection on cerebrocardiac syndrome （CCS） induced by cerebral hemorrhage. Methods： 62 cases of CCS induced by cerebral hemorrhage were divided into treatment group（32 cases） and control group（30 cases）. The control group was given conventional treatment,while the treatment group given conventional treatment combined with Guanxinning injections. The clinical efficacy,ECG,serum myocardial enzyme and adverse reactions were analysed. Results： The total effective rate of the treatment group （84.38%）was was significantly higher than that of the control group （53.33%）（P〈0.01）.The serum AST, LDH,CK, and MB content were （65.59 ± 13.71）、（100.22 ± 17.69）、（40.18 ± 9.46）、（280.82 ± 20.84 ）IU/L respectively in treatment group,and （132.22 ± 16.78）、（219.97 ± 29.54）、（84.13 ± 11.62）、（422.51 ± 33.76）IU/L respectively in control group;the treatment group was significantly lower （P〈0.001）.The two groups had no significant adverse reaction. Conclusion： Guanxinning Injections can improve the clinical symptoms,correct the cardiac electrical abnormalities, and reduce the myocardial enzyme level of CCS induced by cerebral hemorrhage.