丹参川芎嗪对不稳定型心绞痛的疗效及血清可溶性血管细胞黏附分子1水平的影响

Efficacy of Salvia Miltiorrhiza and Ligustrazine in Treating Unstable Angina and Its Effect on Serum Soluble Vascular Cell Adhesion Molecule-1 Level

目的观察丹参川芎嗪治疗不稳定型心绞痛(UA)的临床疗效并探讨其对血清可溶性血管细胞黏附分子1(sVCAM-1)水平的影响。方法将102例不稳定型心绞痛患者随机分为治疗组和对照组,各51例。对照组给予常规治疗,治疗组加用丹参川芎嗪注射液10 mL静脉滴注,每日1次,均治疗7 d。观察两组患者治疗前后心绞痛疗效、常规心电图ST-T改变、血清sVCAM-1水平变化。结果治疗组在心绞痛疗效、心电图改善方面均显著优于对照组(P<0.05),血清sVCAM-1水平下降程度优于对照组(P<0.01)。结论丹参川芎嗪治疗UA疗效良好,同时可降低血清sVCAM-1水平,稳定易损斑块可能是其治疗UA的机制之一。

Objective To observe the effect of salvia miltiorrhiza and ligustrazine in treating of unstable angina （UA） and its effect on the level of serum soluble vascular cell adhesion molecule-1（sVCAM-1）.Methods One hundred and two patients with UA were randomly divided into the treatment group and the control group,51 cases in each group.All patients were treated with the conventional therapy,but the treatment group was added with Salvia Mihiorrhiza and Ligustrazine Injection 10 mL by intravenously drip,once daily.The period of treatment in the two groups was 7 d.The curative effect on angina pectoris,ST segment changes of routine ECG and the level of serum sVCAM-1 were observed before and after therapy in the two groups.Results The effects of angina pectoris and the ECG improvement in the treatment group were significantly superior to those in the control group（P 〈0.05）; the decreased level of sVCAM-1 in the treatment group was apparently superior to that in the control group（P〈0.01）.Conclusion Salvia miltiorrhiza and ligustrazine has better effect in treating UA and can simultaneously decreases the serum VCAM-1 level.Stablizing the vulnerable plaque might be one of the mechanisms in treating UA.