雾化吸入高渗盐水联合布地奈德、沙丁胺醇治疗婴幼儿毛细支气管炎疗效观察

Effect of aerosol inhalation of hypertonic saline combined with budesonide and salbutamol in the treatment of infant bronchiolitis

目的观察3%高渗盐水联合布地奈德、沙丁胺醇雾化液吸入治疗婴幼儿毛细支气管炎的临床效果。方法将确诊为毛细支气管炎的90例住院患儿随机分为3组。对照组(B组)给予0.9%氯化钠注射液、布地奈德、沙丁胺醇雾化液混合雾化吸入治疗;对照组(C组)给予盐酸氨溴索针剂、布地奈德、沙丁胺醇雾化液混合雾化吸入治疗;治疗组(A组)给予3%氯化钠注射液、布地奈德、沙丁胺醇雾化液混合雾化吸入治疗。比较三组患儿临床症状改善情况、住院天数的改变。结果治疗后三组临床症状、体征均改善,治疗组较2个对照组临床症状、体征改善更明显,平均住院日更短。A组的总有效率优于B组、C组(P<0.05)。结论 3%高渗盐水联合布地奈德、沙丁胺醇雾化液吸入治疗毛细支气管炎能较快缓解临床症状,缩短住院时间。

Objective To observe the efficacy of aerosol inhalation with 3.0% hypertonic saline combined with budesonide and salbutamol in the treatment of children with bronchiolitis. Methods 90 children diagnosed with bronchiolitis were divided into three groups randomly. Control group B was given aerosol inhalation of budesonide, salbutamol and physiological saline ; control group C was given aerosol inhalation of budesonide, salbutarnol and ambrox- ol ;Observation group A was given aerosol inhalation of 3% hypertonic saline, budesonide and salbutamol. The improvement of clinical symptoms and the hospitalization days were compared among the three groups. Results After treatment, the symptoms and signs of the three groups were all improved. But the observation group＇s clinical symptoms improvement was more obvious and its hospitalization days was shorter than those of the two control groups. The total efficient rate of group A was better than that of B and C, P 〈 0. 05. Conclusion Aerosol inhalation of hypertonic saline combined with budesonide and salbutamol can relieve the clinical symptoms and shorten the time of hospitalization of children with bronchiolitis.