卡前列素氨丁三醇与米索前列醇防治高危孕妇剖宫产术后产后出血的临床观察

Clinical analysis of carboprost tromethamine and misoprostol in the prevention of postpartum hemorrhage of high-risk pregnant women after cesarean section

目的比较卡前列素氨丁三醇与米索前列醇对高危产妇剖宫产术产后出血的防治价值。方法将102例行剖宫产分娩的高危产妇随机分为2组。A组52例,给予卡前列素氨丁三醇肌注;B组50例,给予米索前列醇塞肛治疗。比较两组产后出血率、产后2 h及24 h出血量。结果两组产后出血率比较差异无统计学意义(P>0.05);A组产后2 h及24 h出血量均少于B组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇对产后出血的防治效果优于米索前列醇,可提高子宫收缩率,减少产后出血率。

Objective To compare the value of carboprost tromethamine and misoprostol in the prevention and treatment of postpartum hemorrhage in high-risk pregnant women after cesarean section. Methods 102 cases of highrisk pregnant women were randomly divided into 2 groups, 52 cases in group A were treated with carboprost tromethamine,while 52 cases in group B were treated with misoprostol. The postpartum hemorrhage rate and the amount of bleeding were compared between the two groups. Results There was no significant difference in the postpartum hemorrhage rate between the 2 groups （ P 〉 0. 05 ）. The amount of bleeding at postpartum 2 h and 24 h in group A were less than those of group B （ P 〈 0. 05 ）. No significant difference was found in the incidence of adverse reactions between the 2 groups （ P 〉 0. 05 ）. Conclusion Carboprost tromethamine can prevent postpartum hemorrhage, and the effect is superior to that of misoprostol, it can improve the rate of contraction of the uterus, and reduce the rate of postpartum hemorrhage.