神经降压素检测对急性颅脑损伤患者的临床意义

The Clinical Significance of Neurotensin Detection Towards Patients with Acute Craniocerebral Injury

目的:探讨神经降压素(NT)水平变化在急性颅脑损伤的临床意义。方法:选取我院2010年1月至2011年5月收治的急性颅脑损伤患者45例,应用放免法动态测定脑脊液NT含量,并设同期腰麻的择期手术患者20例为对照组,以观察脑脊液NT水平在颅脑损伤组和对照组中变化。结果:颅脑损伤患者急性期脑脊液NT含量较对照组显著升高(P<0.05),且病情越严重,NT含量升高越明显,NT水平与伤情轻重程度明显相关。结论:颅脑损伤患者脑脊液NT水平增高可能是继发性病理损害的重要因素,脑脊液NT动态含量,可用作判断急性颅脑损伤患者预后的客观指标。

Objective： To explore the clinical significance of the change of neurotensin（ NT） level in acute craniocerebral injury. Method： A total of 45 patients with acute craniocerebral injury admitted in our hospital from Jan. 2010 to May 2011 were enrolled in the study. The radioimmunoassay was used to determine the NT content in the cerebrospinal fluid. And 20 cases who accepted selective operations under lumbar anesthesia in the corresponding period were served as the control group in order to observe the change of NT level in the cerebrospinal fluid in the craniocerebral injury group and the control group. Result： The craniocerebral injury patients had a significantly higher NT content in the cerebrospinal fluid in the acute stage compared with the control group（ P＆lt;0.05）. Moreover,the more serious the patient’s condition was,the more obviously the NT content elevated. The NT level was evidently associated with the severity degree of the injury. Conclusion： The elevation of the NT level in the cerebrospinal fluid in the craniocerebral injury patients is probably an important factor of secondary pathological damage. The dynamic content of NT in the cerebrospinal fluid can be used as an objective indicator in estimating the prognosis of acute craniocerebral injury patients.