中西医结合治疗对获得性免疫缺陷综合征合并肺部感染患者生存质量的影响分析

Quality of life of AIDS patients following Chinese traditional medicine plus HIV treatment regular drug

目的 探讨中西医药物结合治疗对获得性免疫缺陷综合征（AIDS）合并肺部感染患者生存质量的改善作用.方法 将60例AIDS合并肺部感染患者按照随机、双盲对照方法分为两组,西药±安慰剂组30例,西药＋中药组30例,患者住院观察时间均为4周.用WHO QOL-HIV生存质量量表加上AIDS相关条目,对两组患者治疗前后生存质量进行调查.结果 西药＋中药组与西药＋安慰剂组治疗前WHO QOL-HIV量表中生活质量、活动能力、健康状况、睡眠、工作能力、休闲机会得分差异均无统计学意义（P均＞0.05）,治疗后西药＋中药组上述各指标得分均高于西药＋安慰剂组[（3.78±0.69）、（2.90±0.77）分,（3.55±0.67）、（2.75 ±0.85）分,（3.55±0.67）、（2.75±0.85）分,（3.18±0.72）、（2.85±0.68）分,（3.66±0.70）、（3.35±0.57）分,（3.03±0.73）、（2.95±0.85）分],差异均有统计学意义（t值分别为-2.79、-2.79、-4.28、-3.08、-4.08、-2.56,P均＜0.05）;西药＋中药组与西药＋安慰剂组治疗前WHO QOL-HIV量表中自己满意度、性生活、人类获得性免疫缺陷病毒对身体影响、生活意义、精力评分差异均无统计学意义（P均＞0.05）,治疗后西药＋中药组各指标得分高于西药＋安慰剂组[（3.51±0.67）、（2.93±0.71）分,（3.13±0.46）、（2.86±0.74）分,（3.96±0.71）、（3.45±0.98）分,（3.66±0.72）、（3.23±0.88）分,（3.23±0.67）、（2.90±0.65）分],差异均有统计学意义（t值分别为-4.38、-2.34、-3.75、-2.76、-2.38,P均＜0.05）,人类获得性免疫缺陷病毒对精神影响组间治疗前比较差异无统计学意义（P＞0.05）,治疗后西药＋中药组低于西药＋安慰剂组[（3.05±0.90）、（3.46±0.87）分],差异有统计学意义（t=2.31,P＜0.05）.结论 中药联合西药治疗能明显改善AIDS合并肺部感染患者的生存质量.

Objective To investigate and evaluate the improvement of the quality of life of pulmonary infection in AIDS patients treated by Chinese traditional treatment combined Western medicines treatment.Methods Sixty cases with HIV infection combined with pulmonary infection were selected as our subjects.They were randomly divided into two groups and each group was 30 cases.Patients in western medicine group were given medicine plus placebo,and in Chinese medicine group were given west medicine combined with traditional Chinese medicine.Patients hospitalized for 4 weeks.WHO QOL-HIV plus AIDS-related quality of life scale were used to collect the information about quality of life.Results There were no significant difference between two groups in terms of quality of life,life activity,health status,sleep status,ability to work,leisure opportunities scores at before treatment （P ＞ 0.05）.After treatment,the score of quality of life,life activity,health status,sleep status,ability to work,leisure opportunities in patients of Chinese group were （3.78 ± 0.69）,（3.55 ± 0.67）,（3.55 ± 0.67）,（3.18 ± 0.72）,（3.66 ± 0.70）,（3.03 ± 0.73） respectively,higher than that of western medicine group （（2.90 ± 0.77）,（2.75 ± 0.85）,（2.75 ± 0.85）,（2.85 ± 0.68）,（3.35 ± 0.57）,（2.95 ± 0.85） respectively,t =-2.791,-2.791,-4.28,-3.08,-4.08,-2.56,P ＜ 0.05）.There were no significant differences between the two groups in the terms of the score of satisfaction,sex ability,HIV impaction on the body,the meaning of life,the energy aspects of patients at before treatment （P ＞ 0.05）,but after treatment,these scores in Chinese medicine group were higher that in the control group （（3.51 ± 0.67） vs.（2.93 ±0.71）,（3.13±0.46） vs.（2.86±0.74）,（3.96±0.71） vs.（3.45 ±0.98）,（3.66±0.72） vs.（3.23 ± 0.88）,（3.23 ± 0.67） vs.（2.90 ± 0.65））,and the differences were statistically significant （t =-4.38,-2.34,-3.75,-2.76,-2.38,P ＜ 0.05）.There was no significant difference in the term of the mental effect of HIV within groups at before treatment,but after treatment,the score in Chinese group was lower than the Western group （（3.05 ± 0.90） vs.（3.46 ± 0.87）,t =2.31,P ＜ 0.05）.Conclusion Chinese medicine combined western medicine can significant improve the quality of life of HIV patients with pulmonary infection.