α_(1A)受体阻滞剂在前列腺癌中的应用

Alpha 1A-antagonist for the Treatment of Prostatic Cancer

目的 :探讨 α1 A受体阻滞剂坦索罗辛对改善前列腺癌患者下尿路梗阻症状的作用。方法 :对存在有下尿路梗阻症状的2 6例前列腺癌患者 ,在进行联合雄激素阻断治疗的同时 ,加用 α1 A受体阻滞剂盐酸坦索罗辛。结果 :治疗后 2周和 4周 ,治疗组的最大尿流率 ( Qmax)、国际前列腺症状评分 ( I-PSS)、残余尿量 ( PVR)均比对照组有显著性改善 ( P<0 .0 5)。结论 :α1 A受体阻滞剂坦索罗辛可有效地改善前列腺癌患者下尿路梗阻症状。

Objective[WT5,5”BZ]:To evaluate the clinical efficacy of alpha 1A antagonist (Tamsulosin) for prostatic cancer (PCa) patients with low urinary tract symptoms (LUTS). Methods:The twenty six PCa patients with LUTS were treated by orchiectomy to blockade the effect of androgen and combined with Tamsulosin. Results:After two weeks and four weeks treatment, the parameters in maximum flow rate (Qmax). Internation Prostate Symptom Score (I PSS) and postvoid residual urine (PVR) were much improvement in patients taking Tamsulosin compared with the controls. Conclusion:0.2 mg Tamsulosin once a day was effective to treat PCa patients with LUTS. [