高压氧联合多沙唑嗪治疗高原条件下Ⅲ型前列腺炎的临床研究

Clinical reaserch of hyperbaric oxygenation combined with doxazosin in the treatment ofⅢtype prostatitis in plateau

目的探讨高压氧联合多沙唑嗪治疗高原条件下Ⅲ型前列腺炎的疗效和机制。方法将94例Ⅲ型前列腺炎患者分为多沙唑嗪治疗的多沙唑嗪组(n=31)、高压氧治疗的高压氧组(n=28)和多沙唑嗪联合高压氧治疗的联合治疗组(n=35),治疗时间为8周;治疗前、后分别进行前列腺液常规、前列腺液细菌培养、精液精子计数、精子活动度等检查。采用慢性前列腺炎症状指数评分(NIH-CPSI)对症状及疗效进行评测和比较,并记录不良反应。结果 3组患者治疗前较治疗后在疼痛或不适症状评分、排尿症状评分、生活质量评分及总分4项均有明显改善;联合治疗组总有效率(82.9%)较多沙唑嗪组(70.0%)、高压氧组(73.7%)显著,差异有统计学意义(P<0.05)。3组患者治疗后前列腺液常规均有一定好转,联合治疗组变化最为明显,差异有统计学意义(P<0.05)。3组患者治疗前精液精子计数、精子活动度较健康人均有一定程度降低,治疗后联合治疗组有明显改善,差异有统计学意义(P<0.05)。无并发症发生。结论高压氧联合甲磺酸多沙唑嗪治疗高原条件下Ⅲ型前列腺炎安全有效。

Objective To investigate the effect of treatment and mechanism with hyperbaric oxygenation and doxazosin in pa-tients with Ⅲ type prostatitis in plateau .Methods A total of 94 patients with Ⅲ type prostatitis were divided randomizedly into hyperbaric oxygenation group （n=28） ,doxazosin treated group （n=31） and hyperbaric oxygenation and doxazosin combining trea-ted group （n= 35） .And then they were evaluated in 8 weeks treatment respectvely by the National Institutes of Health Chronic Prostatitis Symptom Index （NIH-CPSI） and adverse events .Prostate fluid and semen routine were examed .Results All three groups got the improved CPSI after treatment ,oxygenation-doxazosin combining treated group（82 .9% ）was better than that of oxy-genation and doxazosin treated group（73 .7% and 70 .0% ）（P〈0 .05） .Results of prostate fluid and semen routine examination of combining treated group were significantly improved than before （P〈0 .05） .No complications occurred .Conclusion Combination of hyperbaric oxygenation and doxazosin is a safe and effective therapy in the treatment of Ⅲ type prostatitis in plateau .