枸橼酸铋雷尼替丁治疗老年人胃溃疡53例临床观察

Clinical observation on the effect of ranitidine bismuth citrate on peptic ulcer in elderly patients

目的评价枸酸铋雷尼替丁治疗老年人胃溃疡的疗效和安全性。方法选取上消化道内镜检查示胃溃疡的老年患者53例,给予枸橼酸铋雷尼替丁治疗,0.35 g/次,2次/d,疗程为6周,观察疗效及不良反应。结果枸橼酸铋雷尼替丁疗程结束后复查上消化道内镜,其中胃溃疡治愈45例,好转及缓解6例,未见明显变化2例,此2例后复查病理提示胃癌,观察53例患者均无不良反应发生。结论对于老年胃溃疡患者,枸橼酸铋雷尼替丁疗效明显,倘若正规治疗效果不明显,要警惕胃癌的发生。

Objective To evaluate the effect and safety of ranitidine bismuth citrate on gastric ulcer in elderly patients . Methods Fifty-three elderly patients were diagnosed as gastric ulcer by upper gastrointestinal endoscopy and were treated with raniti -dine bismuth citrate, at a dose of 0.35g once, twice a day, for a treatment course of 6 weeks.Close observations were made on the effects and adverse reactions of the treatment .Results Following termination of the treatment course , the patients were given upper gas-trointestinal endoscopy .Results showed that 45 cases were healed , 6 cases were either improved or alleviated , and 2 cases almost re-mained unchanged .Further examination of the last 2 cases revealed that they were carcinoma of stomach .Observation of all the 53 cases indicated that there were no serious adverse reactions in them .Conclusion Treatment with ranitidine bismuth citrate could produce good effect in the elderly patients with gastric ulcer .If regular treatment failed to respond , one should be highly aware that carcinoma of stomach might have developed .